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Review Article
- Thyroid
- Euthyroid Thyroperoxidase Antibody Positivity during Pregnancy, to Treat or Not to Treat?
- Tim I. M. Korevaar
- Endocrinol Metab. 2022;37(3):387-391. Published online June 29, 2022
- DOI: https://doi.org/10.3803/EnM.2022.301
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- 196 Download
- 2 Web of Science
- 4 Crossref
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Abstract
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ePub - Thyroperoxidase antibody (TPOAb) positivity is a well-known risk factor for thyroid dysfunction during pregnancy and is associated with a suboptimal response to thyroidal stimulation by human chorionic gonadotropin. About 75% of TPOAb positive women are euthyroid and there seems to be a higher risk of predominantly miscarriage and preterm birth in this subgroup. Nonetheless, clinical decision making with regards to gestational levothyroxine treatment remains difficult due to a lack of large randomized trials. Future studies assessing dose-dependent associations and additional biomarkers that can distinguish low-risk from high-risk individuals will be key in disentangling the crude clinical data.
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Citations
Citations to this article as recorded by
- Thyroid autoimmunity and adverse pregnancy outcomes: A multiple center retrospective study
Yun Xu, Hui Chen, Meng Ren, Yu Gao, Kan Sun, Hongshi Wu, Rui Ding, Junhui Wang, Zheqing Li, Dan Liu, Zilian Wang, Li Yan
Frontiers in Endocrinology.2023;[Epub] CrossRef - The Clinical Implications of Anti-thyroid Peroxidase Antibodies in Graves’ Disease in Basrah
Emad S Alhubaish, Nassar T Alibrahim, Abbas A Mansour
Cureus.2023;[Epub] CrossRef - Research Progress on the Influence of Autoimmune Thyroid Disease on Pregnancy Outcome
敏 李
Advances in Clinical Medicine.2023; 13(08): 13720. CrossRef - The Impact of Maternal Hypothyroidism during Pregnancy on Minipuberty in Boys
Karolina Kowalcze, Robert Krysiak, Anna Obuchowicz
Journal of Clinical Medicine.2023; 12(24): 7649. CrossRef
- Thyroid autoimmunity and adverse pregnancy outcomes: A multiple center retrospective study
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